Linfoma primario del SNC en un paciente con SIDA
LINFOMA PRIMARIO DEL SISTEMA NERVIOSO CENTRAL EN UN PACIENTE CON SIDA.
Primary lymphoma of the central nervous system in an AIDS patient.
Víctor Mechán,1 Julio Ramirez,2 Gustavo Wong,3 Elías Quispe,4 Gustavo Cerrillo5 y Luis Campos 6
A 36 year-old man with a 7-year diagnosis of HIV infection and without treatment had generalized seizures during the last five months and, besides, marked weight loss. On examination, he had a left hemiparesis and nuchal rigiditY, dysarthria and apalpable tumor in the right frontoparietal area. CT-scan revealed a right front-parietal tumor of 11 x 9 cm in the frontal area with peritumoral edema compressing the lateral ventricles and more than 5 mm midline deviation. A brain biopsy showed a primary lymphoma (diffuse large B-cell), EBV (+), CD20 (+), Ki 67:80%,CD4: 9 cells/mm3, HIV viral load: 54 352 copies/mL. He was treated with highly antiretroviral therapy (HAART) alone and his general condition improved and the seizures diminished.
Key words. Primary lymphoma, diffuse B large cell lymphoma, AIDS, human immunodeficiency virus, antiretroviral drug, HAART.